Since the initial description of the syndrome that would later be known as Brugada syndrome, many aspects of the disease have been learned, while many concepts have also been changed. A historical landmark on the understanding of the syndrome was the recognition of the first gene (SCN5A gene encoding for the voltage-gated sodium channel) where mutations were related to the disease. That happened in 1998, just six years after the description of the syndrome. Since then, progress has been enormous. Today more than eighteen different genes have been linked to the same phenotype (ST segment elevation). For the SCN5a gene alone, more than 300 mutations have already been reported, resulting in the same phenotype. The question is are we talking about more than 300 different diseases?

This review undertaken at the behest of Dr. Gregory Dendramis is a testament to this young man who has demonstrated not only a keen interest, but a determined drive to dig deep into the wells of knowledge.